| 2021 Draft | ||
| Round One | Player Chosen | Cost |
| 1. San Francisco Giants | P Josh Beckett | $10 |
| 2. Philadelphia Phillies | P Zach Grienke | $10 |
| 3. Kansas City Royals | C Joey Mauer | $10 |
| 4. Cincinatti Reds | 2b BJ Upton | $10 |
| 5. New York Yankees | P Roy Oswalt | $10 |
| 6. Oakland Athletics | 1b Hank Greenberg | $10 |
| 7. Milwaukee Brewers via Seattle Mariners | P Brandon Webb | $10 |
| 8. Texas Rangers | P Scott Shields | $10 |
| 9. Colorado Rockies | P Jason Marquis | $10 |
| 10. Boston Red Sox | P Tomo Ohka | $10 |
| 11. Chicago White Sox via San Diego Padres | 2b Scott Hairston | $10 |
| 12. Texas Rangers via Milwaukee Brewers | P Mike Timlin | $10 |
| 13. Chicago White Sox via Toronto Blue Jays | SS Khalil Greene | $10 |
| 14. Philadelphia Phillies via Montreal Expos | P Dan Wheeler | $10 |
| 15. St. Louis via Minnesota Twins | P Zack Day | $10 |
| 16. Pittsburgh Pirates | P Jung Bong | $10 |
| 17. Atlanta Braves | P Mike Remlinger | $10 |
| 18. Los Angeles Dodgers | 3b Kieth Youliks | $10 |
| 19. Texas Rangers via Chicago Cubs | 1b Justin Morneau | $10 |
| 20. New York Mets | P Derek Lowe | $10 |
| 21. Chicago White Sox | 2b Danny Garcia | $10 |
| 22. Baltimore Orioles | CF Chone Figgins | $10 |
| 23. Chicago White Sox via Houston Astros | P Jeremy Griffiths**** | $10 |
| 24. St Louis via Cleveland Indians by way of Philadelphia and Minnesota | 1b Lucerne Blue | $10 |
| 25. Anaheim Angels | P Scott Williamson | $10 |
| 26. Seattle Mariners via Detroit Tigers by way of Milwaukee | RF Aaron Guiel | $10 |
| 27. Minnesota via St. Louis Cardinals | P Horacio Ramirez | $10 |
| 28. San Francisco Giants via Florida Marlins | SS Ramon Santiago | $10 |
| Round Two | ||
| 1. San Francisco Giants | 3b Chris Stynes | $8 |
| 2. Philadelphia Phillies | SS Red Kress | $8 |
| 3. Seattle Mariners via Kansas City Royals by way of Milwaukee | SS Erick Almonte | $8 |
| 4. Cincinatti Reds | LF Jason Ellison | $8 |
| 5. Milwaukee Brewers via New York Yankees | P Steven Randolph | $8 |
| 6. Oakland Athletics | P Joe Borowski | $8 |
| 7. Seattle Mariners | P Oscar Villareal | $8 |
| 8. Texas Rangers | P Kevin Grybowski | $8 |
| 9. Colorado Rockies | P Jason Davis | $8 |
| 10. Boston Red Sox | P Jose Cruz | $8 |
| 11. Cleveland Indians via San Diego Padres | 1b Joey Kuehles | $8 |
| 12. Detroit via Milwaukee Brewers | LF Johnny Stone | $8 |
| 13. Cleveland Indians via Toronto Blue Jays | RF Bobby Kielty | $8 |
| 14.Chicago White Sox via Montreal Expos | C Bobby Hammock | $8 |
| 15. Philadelphia Phillies via Minnesota Twins | P Brian Reith | $8 |
| 16. Pittsburgh Pirates | P Billy Traber | $8 |
| 17. Atlanta Braves | RF Reed Johnson | $8 |
| 18. Los Angeles Dodgers | C Koyie Hill | $8 |
| 19. Montreal Expos via Texas by way of Chicago (N) | P Jason Boyd | $8 |
| 20. Texas Rangers via New York Mets | RF Austin Kearns | $8 |
| 21. Chicago White Sox | RF Gabe Gross | $8 |
| 22. New York Mets via Baltimore Orioles | C Paul Hoover | $8 |
| 23. Cleveland Indian via Houston Astros | P Gary Knotts | $8 |
| 24. Cleveland Indians | CF Joe Borchard | $8 |
| 25. Anaheim Angels | 2b Bobby Hill | $8 |
| 26. Philadelphia Phillies via Detroit Tigers | P Juan Rincon | $8 |
| 27. St. Louis Cardinals | 2b Nelson Bry | $8 |
| 28. Seattle Mariners via Florida Marlins | 2b Jose Flores | $8 |
| Round Three | ||
| 1. San Francisco Giants | Skip Draft | |
| 2. Cincinati Reds via Philadelphia Phillies | P Jose Valverde | $6 |
| 3. Kansas City Royals | 1b Ken Harvey | $6 |
| 4. Milwaukee Brewers via Cincinatti Reds | LF Chin Feng Chen | $6 |
| 5. Cleveland Indians via New York Yankees | 2b Juan Bonilla | $6 |
| 6. Oakland Athletics | 3b Garrett Atkins | $6 |
| 7. Seattle Mariners | P Dan Wright | $6 |
| 8. Texas Rangers | Skips Draft | |
| 9. Colorado Rockies | 2b Jose Nieves | $6 |
| 10. Boston Red Sox | 1b Bruce Bochte | $6 |
| 11. Cleveland Indians via San Diego Padres | LF Dave Engle | $6 |
| 12. Milwaukee Brewers | CF Dustan Mohr | $6 |
| 13. Toronto Blue Jays | P Chad Harville | $6 |
| 14. Montreal Expos | LF Jason Bay | $6 |
| 15. Minnesota Twins | 3b Billy Rogell | $6 |
| 16. Pittsburgh Pirates | 2b Marco Scutaro | $6 |
| 17. Atlanta Braves | Skips Draft | |
| 18. Los Angeles Dodgers | Skips Draft | |
| 19. Chicago Cubs | C Vance Wilson | $6 |
| 20. New York Mets | LF Chad Allen | $6 |
| 21. Chicago White Sox | Skips Draft | |
| 22. Baltimore Orioles | Skips Round | |
| 23. Cleveland Indians via Houston Astros | Skips Round | |
| 24. Cleveland Indians | Skips ROund | |
| 25. Anaheim Angels | SS Pee Wee Reese | $6 |
| 26. Detroit Tigers | SS Eddie Montague | $6 |
| 27. St. Louis Cardinals | Skips Round | |
| 28. Florida Marlins | Skips Round | |
| Round Four | ||
| 1. San Francisco Giants | Skips draft | |
| 2. Philadelphia Phillies | Skips draft | |
| 3. Kansas City Royals | P Matt Blank | |
| 4. Cincinatti Reds | Skips draft | |
| 5. New York Yankees | Skips draft | |
| 6. Oakland Athletics | 2b Lindo Storti | $4 |
| 7. Seattle Mariners | Skips draft | |
| 8. Texas Rangers | Skips draft | |
| 9. Colorado Rockies | P Cap Crowell | $4 |
| 10. Boston Red Sox | Skips draft | |
| 11. San Diego Padres | Skips draft | |
| 12. Milwaukee Brewers | Skips draft | |
| 13. Toronto Blue Jays | RF Izzy Alcantara | $4 |
| 14. Montreal Expos | Skips draft | |
| 15. Minnesota Twins | Skips draft | |
| 16. Pittsburgh Pirates | C Kevin Cash | $4 |
| 17. Atlanta Braves | Skips draft | |
| 18. Los Angeles Dodgers | Skips draft | |
| 19. Chicago Cubs | 3b Jamey Carroll | $4 |
| 20. New York Mets | Skips draft | |
| 21. Chicago White Sox | Skips draft | |
| 22. Baltimore Orioles | Skips draft | |
| 23. Houston Astros | Skips draft | |
| 24. Cleveland Indians | Skips draft | |
| 25. Anaheim Angels | 3b Pedro Manterro | $4 |
| 26. Detroit Tigers | SS Eric Bruntlett | $4 |
| 27. St. Louis Cardinals | Skips draft | |
| 28. Florida Marlins | Skips draft | |
| Round Five | ||
| 1. San Francisco Giants | Skips Draft | |
| 2. Philadelphia Phillies | C Greg Zaun | $2 |
| 3. Kansas City Royals | SS Chuck Abbott | $2 |
| 4. Cincinatti Reds | Skips Draft | |
| 5. New York Yankees | Skips Draft | |
| 6. Oakland Athletics | P Michael Tejera | $2 |
| 7. Seattle Mariners | Skips Draft | |
| 8. Texas Rangers | Skips Draft | |
| 9. Colorado Rockies | P Jack Sanford | |
| 10. Boston Red Sox | Skips Draft | |
| 11. San Diego Padres | Skips Draft | |
| 12. Milwaukee Brewers | Skips Draft | |
| 13. Toronto Blue Jays | LF Cory DeHaan | $2 |
| 14. Montreal Expos | Skips Draft | |
| 15. Minnesota Twins | Skips Draft | |
| 16. Pittsburgh Pirates | SS Jason Romano | $2 |
| 17. Atlanta Braves | Skips Draft | |
| 18. Los Angeles Dodgers | Skips Draft | |
| 19. Chicago Cubs | Skips Draft | |
| 20. New York Mets | Skips Draft | |
| 21. Chicago White Sox | Skips Draft | |
| 22. Baltimore Orioles | Skips Draft | |
| 23. Houston Astros | Skips Draft | |
| 24. Cleveland Indians | Skips Draft | |
| 25. Anaheim Angels | 3b Toby Harrah | |
| 26. Detroit Tigers | RF Crhis Brumbaugh | $2 |
| 27. St. Louis Cardinals | Skips Draft | |
| 28. Florida Marlins | Skips Draft | |
| Supplemental Picks | ||
| 1. San Francisco Giants | Skips | |
| 2. Philadelphia Phillies | Skips | |
| 3. Kansas City Royals | Skips | |
| 4. Cincinatti Reds | Skips | |
| 5. New York Yankees | Cf Mike Twirlinger | |
| C Andy Allanson | ||
| 2b Andy Kata | ||
| CF Paul Householder | ||
| 6. Oakland Athletics | LF Greg Luzkinski | |
| 1b Ben Broussard | ||
| 7. Seattle Mariners | ||
| 8. Texas Rangers | C Jim Essian | |
| P Bill Lascshich | ||
| 9. Colorado Rockies | ||
| 10. Boston Red Sox | SS Wilson Betemit | |
| 2b Alex Cora | ||
| 11. San Diego Padres | Skips | |
| 12. Milwaukee Brewers | Skips | |
| 13. Toronto Blue Jays | 1b Toby Rumfeld | |
| P Nick Tapani | ||
| 14. Montreal Expos | RF Bill Robinson | |
| SS Clint Barnes | ||
| P Alex Scaeffer | ||
| P Fernando Rodney | ||
| 3b Tyler Houston | ||
| 15. Minnesota Twins | Skips | |
| 16. Pittsburgh Pirates | Skips | |
| 17. Atlanta Braves | CF Catfish Metkovich | |
| C Fernando Lunar | ||
| 18. Los Angeles Dodgers | Skips | |
| 19. Chicago Cubs | Skips | |
| 20. New York Mets | Skips | |
| 21. Chicago White Sox | Skips | |
| 22. Baltimore Orioles | SS Rod Gaspar | |
| 23. Houston Astros | P Cal Hogue | |
| 3b Chris Donnels | ||
| 24. Cleveland Indians | Skips | |
| 25. Anaheim Angels | P Dan Reichert | |
| P Jim Kern | ||
| 26. Detroit Tigers | Skips | |
| 27. St. Louis Cardinals | SS Ramon Vazquez | |
| P Lorenzo Barcelo | ||
| 28. Florida Marlins | P Luther Hackman | |
| P Harry Arcia | ||
| P Bill Henderson | ||